Although TP53 mutations were more common in EBV-negative PT-DLBCL than in EBV-positive PT-DLBCL and de novo DLBCL, the overall mutational frequency, including gene clusters related to the NF-κB pathway and epigenetic modifiers, in EBV-negative PT-DLBCL was similar to that in de novo DLBCL. Here, TP53 is linked to diffuse large B-cell lymphoma.