SIRT1 and myocardial infarction: Curcumin treatment was also shown to protect against heart fibrosis following myocardial infarction via sirtuin-1 activation [27], senescence of vessels [28], oxidative stress and force recovery in muscles of aged rats [49], oxidative damage of mitochondria in ischemia-reperfusion models [48], and autophagy and apoptosis in myocytes exposed to hypoxia/reoxygenation conditions [50].