Further studies comparing conventional and immunohistochemical (IHC) staining indicated that those micro-cancers looked avascular on H&E stained slide, but CD34 staining revealed an intratumoral network of endothelium, suggesting that such an endothelial network could be 1) functional and vital for supplying nutrients to cancer cells, and 2) vulnerable to VDA attack resulting in nearly complete tumor necrosis [72]. Here, CD34 is linked to cancer.