In the CARISA trial (Combination Assessment of Ranolazine in Stable Angina), ranolazine treatment for 12 weeks reduced HbA1c levels by 0.7 ± 0.18% in patients with chronic angina (189 with T2DM and 634 subjects without the disease) regardless of concomitant insulin or oral hypoglycemic therapy [11]. Here, INS is linked to type 2 diabetes mellitus.