A tumor microenvironment (TME) is composed of cancer cells in association with a variety of other cells—stromal cells, fibroblasts, myofibroblasts, endothelial cells, immunosuppressive leukocytes like regulatory T cells (Tregs) and other suppressor cells, which inhibit immunity through cell contact or secretion of various cytokines [3] (such as transforming growth factor beta (TGF-β) [4]). This evidence concerns the gene TGFB1 and neoplasm.