ANK2 variants are associated with cardiovascular phenotypes including sinus node disease, atrial fibrillation, heart rate variability, catecholaminergic polymorphic ventricular tachycardia (CPVT), ACM, cardiomyopathy, syncope, and sudden cardiac death. This evidence concerns the gene ANK2 and catecholaminergic polymorphic ventricular tachycardia.