Recently, ANK2 variants have been identified in individuals with arrhythmogenic right ventricular cardiomyopathy (ARVC) [27], a disease characterized by a severe structural and electrical cardiac phenotype that involves the fibrofatty replacement of healthy myocardium, malignant arrhythmias, and even sudden cardiac death [56]. This evidence concerns the gene ANK2 and Arrhythmogenic right ventricular dysplasia.