Furthermore, caspase-8 has recently been reported to mediate the activation of the Nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, comprising the NLRP3 scaffold, apoptosis-associated speck-like protein containing CARD (ASC) and caspase-1, which participates in various diseases, including autoimmune disorders, type 2 diabetes, atherosclerosis, gout, and obesity [15,22,23,24]. Here, NLRP3 is linked to obesity due to melanocortin 4 receptor deficiency.