Specifically, oral manifestations such as candidiasis, oral warts, herpes labialis, and aphthous stomatitis, which represent some of the first signs of HIV immunodeficiency, could become, in these cases, very important diagnostic, and especially prognostic, indices; this is also due to the correlation existing between oral lesions, viral load, and CD4+ T-cell count. Here, CD4 is linked to Recurrent aphthous stomatitis.