They demonstrated that greater age (HR 4.36 [95% CI, 1.33–14.29], p = 0.015), NA treatment (HR 0.28 [0.13–0.62], p = 0.002), BCP mutations (HR 12.74 [1.74–93.11], p = 0.012), high HBcrAg (HR 2.77 [1.07–7.17], p = 0.036), and high gamma glutamyl transpeptidase levels (HR 2.76 [1.49–5.12], p = 0.001) were factors significantly associated with HCC development. The gene discussed is OPN1SW; the disease is hepatocellular carcinoma.