Using HBcrAg levels, HBV DNA levels, HBeAg status, the covariates of HBV genotype status, and basal core promotor (BCP) status, a Cox proportional hazard model showed that HBcrAg > 2.9 log U/mL and BCP mutations were independently associated with HCC occurrence [48]. The gene discussed is OPN1SW; the disease is hepatocellular carcinoma.