Also, the lower frequency of TERTp mutations in BCG-treated recurrent tumors when compared to primary tumors could be explained by the enhanced BCG action on tumor cells harboring TERTp mutations, leading to clonal selection pressure towards cells harboring other alterations (such as FGFR3 mutations) in recurrent tumors, hence shifting the prevalence of recurrent tumors towards TERTp-negative tumors. This evidence concerns the gene FGFR3 and neoplasm.