Other markers (Alpha-1-acid glycoprotein 2 (ORM2), Alpha-1B-glycoprotein (A1BG), Haptoglobin (HP), and Leucine-rich alpha-2-glycoprotein (LRG1), etc.)were found to create an ambiguous core involved in cancer development but also to exactly promote tumor progression in the early stages. Here, ORM2 is linked to cancer.