Other markers (Alpha-1-acid glycoprotein 2 (ORM2), Alpha-1B-glycoprotein (A1BG), Haptoglobin (HP), and Leucine-rich alpha-2-glycoprotein (LRG1), etc.)were found to create an ambiguous core involved in cancer development but also to exactly promote tumor progression in the early stages. This evidence concerns the gene LRG1 and cancer.