Moreover, CDK5 plays a relevant role in tumorigenesis in a number of cancers, such as breast, pancreas and neuroendocrine thyroid carcinomas [83,84,85], and has been recently demonstrated to directly phosphorylate ERK5 in T732, enhancing ERK5 nuclear accumulation and modulating the oncogenic ERK5-AP1 axis in colorectal cancer [86]. This evidence concerns the gene MAPK7 and colorectal cancer.