Indeed, ERK5 localizes in the nucleus of CLB-BAR and CLB-GE human neuroblastoma cell lines even in the presence of the ERK5 inhibitor XMD8-92 [111], and neither BIX02189 nor XMD8-92 are able to suppress ERK5 nuclear accumulation when used alone, but only in combination with vemurafenib, in melanoma cells expressing BRAFV600E [88]. Here, MAPK7 is linked to melanoma.