STAT3 has also been shown to cross-talk with Ras signaling to further promote the oncogenic transformation of human mammary epithelial cells [133], and recent studies of ovarian cancer have pointed to STAT3’s ability to promote metastasis, chemoresistance, and EMT via MAPK/PI3K/AKT signaling downstream of p53/Ras signaling [134]. This evidence concerns the gene STAT3 and ovarian cancer.