An example of this can be seen where stable microvasculature from the perivascular niche maintains tumor dormancy in breast cancer cells through endothelial cells expressing thrombospondin-1 (THBS1) [71], an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and a known inhibitor of neovascularization and tumorigenesis. Here, THBS1 is linked to breast cancer.