In CRS, activated T cells produce cytokines, including monocyte chemoattractant protein-1 (MCP-1), IL-8, IL-10, IL-2, interferon gamma (IFNγ), IL-6, and IL-6R [186,187,188,189,190], which recruit more immune cells and lead to a highly inflammatory state. This evidence concerns the gene IFNG and congenital rubella syndrome.