STAT3 and neoplasm: In contrast to this, the small molecule inhibitor EC359, which has been shown to directly interact with LIFR to block its interactions with LIF, OSM, CNTF, and CT-1, reduced LIFR-mediated activation of multiple gene targets, STAT3 activity, and downstream target genes, and suppressed TNBC xenograft and PDX tumor growth in vivo [141].