Among the common mutations in colorectal cancers, NRAS mutations were frequent (p.Glu61Lys, p.Glu61Arg, and p.Glu61Leu missense/common mutations in C1, C3, and C7, respectively), although this event has been previously reported to be relatively rare (<5%) in colorectal cancers [15]. This evidence concerns the gene NRAS and colorectal cancer.