APC and cancer: In colorectal cancers, eight genes enriched with lesion-common mutations include known cancer-related genes involved in the colorectal adenoma–carcinoma sequence, such as APC, KRAS, and TP53. For example, APC mutations occur early in the dysplastic epithelium and are followed by mutations in KRAS and TP53 during the dysplasia–adenoma and adenoma–carcinoma sequences, respectively [5,6].