The involvement of GOLPH3 in cytokinesis is highly relevant to cancer biology because cytokinesis failures lead to tetraploidy, which promotes tumorigenesis and chromosome instability (CIN), accelerates cancer heterogeneity and evolution, contributes to increased resistance to drug treatment, and has been correlated with poor prognosis in colon cancer patients [43,44,45,46]. Here, GOLPH3 is linked to cancer.