MAPK1 and glioblastoma: Finally, Peng and co-workers [76] demonstrated that GOLPH3 is also a direct target of miR-299-5p in GBM cell lines (T98G and A172); moreover, miR-299-5p knockdown makes GBM cells sensitive to temozolomide (TMZ) both in vitro and in vivo by impairing cell proliferation and invasion and promoting apoptosis through the inhibition of the ERK signaling pathway.