GOLPH3 and breast cancer: To investigate how the overexpression of GOLPH3 might influence its roles in the oncogenesis of breast cancer, the group of Mardones compared some of the biochemical and cellular characteristics of GOLPH3 in the two human breast cancer cell lines MCF7 and MDA-MB-231 with those of GOLPH3 in the non-tumorigenic human breast cell line MCF 10A [81].