GOLPH3 and central nervous system cancer: In human glioma tissues, GOLPH3, mTOR and YB1 (one of mTOR target genes, involved in cell migration and invasion) were all upregulated and exhibited a positive correlation with each other, while a downregulation of GOLPH3 through RNAi was sufficient to lower the levels of both mTOR and YB1 in these cells, thus inhibiting their motility.