The role of GOLPH3 in CNS tumor etiology was first proposed by Li and collaborators in 2011 [62] who found that more than half of their patients affected by glioma are positive for the overexpression of either GOLPH3 protein or RNA and that the amount of GOLPH3 expression in the glioma patients is associated with the severity of the tumor. This evidence concerns the gene GOLPH3 and central nervous system cancer.