GOLPH3 and glioblastoma: Similar results were obtained by inhibiting YB1 using specific siRNA or by using INK128, an inhibitor of both mTOR complexes (mTORC1/2) [14]; in both cases, artificially increasing the GOLPH3 levels alone had no effects on cell motility, showing that the mTOR-YB1 pathway was pivotal for GBM invasiveness.