Consistent with the findings that overexpression of TXNIP promotes DNA damage in esophageal adenocarcinoma [48], senescence in vascular endothelial cells [49], we demonstrated that TXNIP, may function downstream of PRMT5 to regulate DNA damage signaling and p21-mediated cellular senescence in U2 OS cells. Here, CDKN1A is linked to esophageal adenocarcinoma.