CD4 and HIV-1 infection: Despite the susceptibility of TSCM cells to HIV-1 infection [91], the proportion of CD8+ TSCM cells has been previously inversely correlated to viral replication, and immune activation [92], which is in agreement with our study, and the preservation of the CD4+ TSCM population was associated with a better prognosis in both HIV-1 and SIV infection [92,93].