Also, there was significantly higher positive expression of p-mTOR and p-eIF4E proteins in lung ADC than that in lung SCC, which might indicate the p-mTOR and p-eIF4E were associated with histological type and could be used to improve the IHC staining algorithm currently used to sub-classify NSCLC into lung adenocarcinomas versus lung squamous subtypes. Here, EIF4E is linked to lung adenocarcinoma.