The overall survival rates (OS) of NSCLC patients with positive expression of p-Akt, p-mTOR and p-eIF4E proteins were significantly lower than those with negative expression (P = 0.045, Fig 3A; P = 0.030, Fig 3B; and P = 0.001, Fig 3C, respectively). The gene discussed is EIF4E; the disease is non-small cell lung carcinoma.