Biological processes significantly associated with the mechanisms of PDIs in gliomas included protein folding in endoplasmic reticulum, regulation of intrinsic apoptotic signaling pathway in response to DNA damage by P53 class mediator, tumor necrosis factor-mediated signaling pathway, regulation of tyrosine phosphorylation of STAT3 protein, ECM receptor interaction, JAK-STAT signaling pathway, amino sugar and nucleotide sugar metabolism, P53 signaling pathway, DNA replication, and mismatch repair (Figure 8A). The gene discussed is TNF; the disease is glioma.