GISTIC 2.0 analysis identified several significant regions of amplification harboring multiple oncogenes in gliomas with a high-risk score, including 1q32.1 (PIK3C2B), 4q12 (PDGFRA), 7p11·2 (EGFR), and 12q14·1(CDK4). Here, CDK4 is linked to glioma.