Furthermore, amplification peaks of oncogenes (PIK3C2B, PDGFRA, EGFR, CDK4), and deletion peaks of tumor suppressor genes (TUSC1, CDKN2A, CDKN2B, PTEN, FAS, BNIP3) were detected in the gliomas with a high risk score. Here, CDK4 is linked to central nervous system cancer.