In the TCGA LGGGBM cohort, the mRNA expression of P4HB, PDIA3, PDIA4, PDIA5, PDIA6, ERP27, ERP29, ERP44, TMX1, TMX3, TMX4, TXNDC5, TXNDC12, AGR3, and DNAJC10 in gliomas with mutant IDH were lower in comparison to those in gliomas with wild-type IDH. The gene discussed is TMX3; the disease is central nervous system cancer.