High mutation frequency in IDH1, TP53, and ATRX were associated with low PDI signature in gliomas (IDH1, 89% vs. 17%; TP53, 48% vs. 31%; ATRX, 32% vs. 15%), whereas TTN, MUC16, and PIK3CA were associated with high PDI signature (TTN, 10% vs. 24%; MUC16, 8% vs. 13%; PIK3CA, 5% vs. 11%) (Figure 3A–3B). This evidence concerns the gene P4HB and central nervous system cancer.