In the TCGA LGGGBM cohort, the mRNA expression of P4HB, PDIA3, PDIA4, PDIA5, PDIA6, ERP27, ERP29, ERP44, TMX1, TMX3, TMX4, TXNDC5, TXNDC12, AGR3, and DNAJC10 in gliomas with mutant IDH were lower in comparison to those in gliomas with wild-type IDH. This evidence concerns the gene AGR3 and central nervous system cancer.