TNF and lymphoma: The plasmid DNA encodingCNGRCG-TNF and ACDCRGDCFCG-TNF (pNGR-TNF and pRGD-TNF, respectively)displayed growth inhibition of subcutaneous murine B16F1 melanomasand RMA-T lymphomas after intramuscular injection.110 RGD-TNFα was also evaluated for its ability to enhancethe antitumor effect of chemotherapy; however NGR-hTNFα wasmostly chosen for clinical trials.