Prostate cancer is stratified as low-, intermediate-, and high-risk disease based on tumor stage, PSA level at diagnosis, and Gleason score.2 Treatment options for localized prostate cancer include active surveillance (reserved for low-risk individuals), radical prostatectomy with possible pelvic lymph node dissection, or radiation therapy (RT) entailing brachytherapy, external beam radiation therapy (EBRT), or both. This evidence concerns the gene KLK3 and prostate carcinoma.