KLK3 and Familial prostate cancer: Prostate cancer is stratified as low-, intermediate-, and high-risk disease based on tumor stage, PSA level at diagnosis, and Gleason score.2 Treatment options for localized prostate cancer include active surveillance (reserved for low-risk individuals), radical prostatectomy with possible pelvic lymph node dissection, or radiation therapy (RT) entailing brachytherapy, external beam radiation therapy (EBRT), or both.