The Rad21 subunit of the Cohesin complex has been shown to act as a tumor suppressor and promoter of pro-inflammatory myeloid polarization in the hematopoietic system, while acting to preserve stemness and prevent differentiation of progenitor cells in the epidermis (Mullenders et al., 2015; Noutsou et al., 2017; Cuartero et al., 2018). The gene discussed is RAD21; the disease is neoplasm.