However, recent studies have reported a rate of 3% to 10% of discordance between molecular MSI testing and MMR immunohistochemistry in colorectal cancers.19 In our study, one of the three MSI‐H cases showed negative expression of nuclear MSH2 and MSH6 proteins and other two cases showed intact nuclear expression of the four MMR proteins. This evidence concerns the gene MSH6 and colorectal cancer.