The third osteosarcoma was derived from a local recurrence of a 51‐year old female and showed a dicentric translocation between the 5′ untranslated region of the RALGPS2 gene and exons 4–17 of NTRK3. The predicted fusion transcript lacked an endogenous start codon (Figure 1C) and, although it introduced an alternative in‐frame start codon just after the breakpoint, this was not sufficient to induce transcription of the downstream functional domains of NTRK3 (Figures 3C and 4C). Here, NTRK3 is linked to osteosarcoma.