It is reported that DUXAP8 can act as a ceRNA of miR‐577 to promote the expression of RAB14, thus promoting the migration and invasion of colorectal cancer cells 31; in renal cell carcinoma, DUXAP8 targets miR‐126 and promotes cancer progression.13 Based on the difference in the expression and role of DUXAP8 and miR‐422a in HCC, we speculated that there was a regulatory relationship between them. The gene discussed is DUXAP8; the disease is hereditary clear cell renal cell carcinoma.