DUXAP8 and esophageal squamous cell carcinoma: Studies show that DUXAP8 exerts a regulatory role in esophageal squamous cell carcinoma, renal cell carcinoma, gastric cancer, and other tumors.11, 12, 13 A recent study reports that in HCC, DUXAP8 repressed tumor suppressor KLF2 transcription through interacting with EZH2.14 However, the function and mechanism of DUXAP8 in HCC needs further exploration.