DUXAP8 and esophageal squamous cell carcinoma: For example, DUXAP8 is upregulated in esophageal squamous cell carcinoma, and its expression is positively correlated with TNM stage and lymph node metastasis, and negatively correlated with patients’ survival rate 12; DUXAP8 is highly expressed in bladder cancer tissues, and knocking down its expression can reduce the cell viability.27 In this study, we demonstrated that DUXAP8 was upregulated in HCC tissues and cells, and its high expression was associated with several adverse clinical features, including increased tumor size, distant metastasis, and increased TNM staging.