Studies show that DUXAP8 exerts a regulatory role in esophageal squamous cell carcinoma, renal cell carcinoma, gastric cancer, and other tumors.11, 12, 13 A recent study reports that in HCC, DUXAP8 repressed tumor suppressor KLF2 transcription through interacting with EZH2.14 However, the function and mechanism of DUXAP8 in HCC needs further exploration. The gene discussed is DUXAP8; the disease is esophageal squamous cell carcinoma.