It is reported that lncRNA GAS5 is downregulated in HCC, and its overexpression can impede cell migration and invasion 25; the expression of lncRNA HOTAIR in HCC is elevated, and patients with high expression of it have a poor prognosis 26; moreover, the expression of lncRNA MALAT1 is also confirmed to be an independent prognostic factor for HCC.10 It is worth noting that the expression of DUXAP8 is closely related to the occurrence and progression of a variety of tumors. The gene discussed is GAS5; the disease is hepatocellular carcinoma.