COL5A2 and Hepatic fibrosis: In COL5A2−/− mice, lack of expression of COL5A2 leads to disorganized type I collagen fibrils, and mice exhibit eye and skin abnormalities.30 The expression of COL5A2 is significantly up‐regulated in association with fibrosis in renal epithelial cell lines and rat liver fibrosis.13, 33 In our previous study, we demonstrated that COL5A2 expression is up‐regulated and correlated with the degree of IUA (Figure 1).