The Nm23‐H1 gene was initially identified as a suppressor of tumor metastasis.30, 31, 32 The downregulation and hetero‐deletion of the gene are closely correlated with the high metastatic potential and poor prognosis of lung cancer.33, 34 Besides, the aberration of the nm23‐H1 gene is often companied by alteration in tumor metastasis‐related genes. The gene discussed is NME1; the disease is lung carcinoma.