In their study, the RANKL expression was increased at both transcript and protein levels in the most metastatic cell line.47 Moreover, osteolytic metastasis has been successfully inhibited in several types of cancer, including multiple myeloma and prostate cancer through the suppression of RANKL signaling.41, 43 This study also found similar results that showed that RANKL expression was upregulated in bone‐specific metastasis L9981‐BoM cells compared to L9981‐Luc cells. This evidence concerns the gene TNFSF11 and Familial prostate cancer.