The downregulation of miR‐660‐5p in bone‐specific metastatic lung cancer cell L9981‐BoM significantly inhibited cell proliferation, migration, and invasion in vitro, whereas the upregulation of miR‐660‐5p in L9981‐Luc significantly promoted lung cancer tumorigenesis and bone‐specific metastasis in vitro and in vivo. This evidence concerns the gene GRHL2 and lung cancer.