However, the principal cause of liver inflammation is gut‐derived lipopolysaccharide (LPS), a prototypical TLR4 agonist.5 Growing evidence suggests that gut‐derived LPS affects the extent of liver damage or even plays a crucial role in certain diseases such as alcoholic liver disease and HCC.18, 19 Contrary to TLR5 agonists, LPS induces high expression of TNF‐α, whose pro‐apoptotic effects through crosstalk with the Fas pathway have been in the focus of recent research.1, 2, 3, 8. Here, TLR4 is linked to hepatocellular carcinoma.