TLR4 signalling and Stat3 are suggested to be involved in hepatocarcinogenesis and tumour progression, and TLR4 signalling was shown to promote HCC proliferation in a Stat3‐dependent manner.17, 18, 45 Therefore, the anti‐apoptotic effect of inflammation that we report here might be beneficial in conditions where apoptosis contributes to liver injury. This evidence concerns the gene TLR4 and hepatocellular carcinoma.