Non‐tumoral neighbouring cells may promote tumour growth by secreting paracrine signals from the tumour microenvironment.34, 35 Previous results from our group have demonstrated that S100B protein is a key neurotrophic factor involved in colon inflammation and its targeting by pentamidine is accompanied by significant amelioration of colitis in mice.20 Despite chronic inflammatory conditions are well‐established risk factors in colon cancer, there is still limited evidence supporting the role of S100B in the pathophysiology of colon cancer. This evidence concerns the gene S100B and malignant colon neoplasm.