S100B and neoplasm: By interacting with the C‐terminus of wtp53, S100B prevents its tetramerization and protein kinase C‐mediated phosphorylation, inhibiting the transcriptional and tumour suppressor activity of wtp53.15, 16 The targeting of enteric glial S100B protein and wtp53/S100B interaction might thus represent a new strategy in colorectal carcinoma therapy.13