S100B is a neurotrophin, constitutionally and specifically expressed by enteric glial cells (EGCs) in the enteric nervous system, which belongs to a multigene family of diffusible Ca2+/Zn2+‐binding proteins.5, 6, 7 It is known that S100B protein overexpression correlates with poor prognosis in melanoma8, 9 and glioma,10 and early relapse following curative resection in colorectal carcinoma patients,11 suggesting its direct involvement in the perpetuation of a tumour‐promoting microenvironment. Here, S100B is linked to central nervous system cancer.