IL22 and acute coronary syndrome: Our previous study revealed significant increases in the peripheral Th22 cell numbers and IL‐22 levels of patients with acute coronary syndrome (ACS) compared to patients with stable angina pectoris (SAP) and control patients, suggesting that the circulating Th22‐type response may have a potential role in the onset of ACS symptoms.23 In this context, we focused on elucidating whether and how Th22 cells and IL‐22 act on AS.