PRAME and acute myeloid leukemia: However, polyclonal reactive plasma cells do not express any of these genes.41 Another study found that expression of ETS‐related genes (ERGs), ecotropic viral integration site‐1 (EVI1) and PRAME could allow a greater distinction between AML and cytogenetically normal AML (CN‐AML) patients, which could be useful for improving their individual prognostic significance and patient risk stratification.42 In the CML cell line model, PRAME overexpression inhibits RAR‐mediated cell differentiation, growth arrest and apoptosis.