Haematological malignancies such as CML and AML as well as lymphomas could be vulnerable to control by the immune system, and effector T cells, which recognize minor histocompatibility antigens and tumour‐associated antigens (TAAs) that are overexpressed in tumour cells, play a key role in this process.49, 50, 51, 52, 53 PRAME is overexpressed in many haematological malignancies but is absent in normal tissues. The gene discussed is PRAME; the disease is neoplasm.