MMP9 and cancer: In particular, reduction of the secretion and activity of MMP‐2 and MMP‐9 has been shown to inhibit cancer cell motility and metastasis.30 In both A549 and H460 cell lines, HJC0152 inhibited the protein expression of MMP2 and MMP9, suggesting that HJC0152 attenuates the ability of these MMPs to degrade the extracellular matrix (Figure 5G and H).