Cancer cells may gain a growth advantage or escape apoptosis and other forms of cell death through alterations in their metabolic regulation.7 Given that STAT3 is a key regulator of cellular metabolism, we employed untargeted metabolomic analysis to study the effect of inhibiting it with HJC0152 on metabolites in A549 NSCLC cells. Here, STAT3 is linked to non-small cell lung carcinoma.