STAT3 and non-small cell lung carcinoma: It has been shown that activated STAT3 protects β‐cells from DNA damage in partial pancreatic duct ligation, the level of DNA damage in β‐cells increased after deletion of STAT3.44 Consistently, another study reported that HT29 cells treated with AG490, a specific inhibitor of STAT3 phosphorylation and activity, had abolished STAT3 phosphorylation and accumulation of γH2AX.13 In line with this, our results showed that decreased phosphorylation of STAT3 in NSCLC cells largely accelerated DNA damage, as monitored by γH2AX formation.