Our previous studies and a report from other groups have shown that STAT3 is a primary target of HJC0152 in breast cancer, head and neck squamous cell carcinoma, glioma, and gastric cancer.19, 20, 33, 34 In this study, we showed that STAT3 expression is a prognostic factor for NSCLC patients (Figure 2A‐C), and that STAT3 is activated in NSCLC cells (Figure 2D and E). Here, STAT3 is linked to central nervous system cancer.