Previously, we found that oxidative stress is an early upstream event of apoptosis in breast cancer cells.17 To assess whether HJC0152 induces apoptosis in lung cancer cells, we performed annexin V‐FITC/PI double staining and analysis using flow cytometry.17 The results showed that treatment with increasing concentrations of HJC0152 induced a corresponding increase in the percentage of apoptotic cells (Figure 3E and F). Here, ANXA5 is linked to lung cancer.