ATP‐binding cassette transporters are a large class of transmembrane proteins involved in substance transport37 and use ATP hydrolysis to transport diverse substrates (eg, amino acids, lipids, lipopolysaccharides, inorganic ions, polypeptides, carbohydrates and various drugs) across cell and organelle membranes, thus in association with many diseases and cancers.38 In HJC0152‐treated A549 cells, 8 altered metabolites were involved in ABC transporter pathways (Table 1). This evidence concerns the gene ABCG2 and cancer.