ENO2 and Vertigo: In addition, the NSE biomarker in patients with acute vertigo had the area under the ROC curve of 96.9 (95% CI: 93.7 – 100.0; figure 2), and at a cut-off point of above 18.12 ng/ml, had sensitivity of 100.00% and specificity of 89.47%, indicating the central nature of vertigo.