S100B had the area under the ROC curve of 90.3 (95% CI: 80.7 – 99.8) for differentiating the causes of acute vertigo (figure 2), and at the cut-off point of above 119.68 pg/l, had sensitivity of 90.00% and specificity of 92.00%, in detecting cases with abnormal MRI findings (central cause of vertigo). The gene discussed is S100B; the disease is Vertigo.