CPS1 and hepatocellular carcinoma: The network was used to investigate the role of CPS1, which codes for a protein that catalyzes the first step of the urea cycle, and CAD, which codes for a trifunctional protein catalyzing the first three steps of de novo pyrimidine biosynthesis pathway, in normal metabolism, and in turn, metabolic reprogramming in HCC.7,8,22–25