Altogether, the degree of untethering at the CDR seems to correlate with disease susceptibility or severity between the different variants (N68K ~ T96K < R62H < R47H < D86V < < T66M) and provides additional support for a link between TREM2 D86V and FTD, with a mechanism similar to T66M, albeit less severe. The gene discussed is TREM2; the disease is frontotemporal dementia.