Increased EMP levels were found in several pathological conditions such as hypertension, dyslipidemia, atherosclerosis, metabolic syndrome and coronary artery disease.8,11,44–47 Sabatier et al18 have shown that the levels of EMPs were elevated in T1DM and associated with microvascular complications, suggesting that EMPs could be a marker of diabetes-related vascular disease. This evidence concerns the gene MAEA and metabolic syndrome.