A case of malignant insulinoma, Case 7, was mixed trabecular and solid histopathological pattern with slightly large cytoplasms, which were partly but moderately positive for insulin in all tumor cells and less stained for CgA in the tumor cell cytoplasm (about 1% of tumor cells), and were diffusely and strongly positive for SPY (Figure not shown). This evidence concerns the gene CGA and neoplasm.