A case of benign PPoma, Case 3, was gyriform pattern of a few cell-layers, which were negative for insulin, glucagon, and somatostatin but strongly positive for only PP with the same staining intensity of the normal PP cells, and tumor cells were diffusely and weakly immunostained for CgA and diffusely and strongly for SPY (Table 2, Figure 3A-F). The gene discussed is INS; the disease is neoplasm.