CGA and neoplasm: A part of this tumor was acutely infarcted at the outer margin of the tumor with disrupted cell membrane, and the nearly entire tumor tissue remained positive for CgA while the infarcted area was negative for SPY with a weak remaining staining at the outer tumor margin, suggesting that the SV quickly disappeared after infarction while preserving CgA-positive PP secretory granules (Table 2, Figure 3N and O).