The tumor metastasized to the liver after hemipancreatectomy and spread diffusely to the remaining pancreas, liver, lungs, and bone marrows after chemotherapy, two and a half years later the histopathology of the recurrent tumor was small cell anaplastic tumor, which was negative to PP, CgA, and SPY (Table 1, Figure not shown)[20,21]. This evidence concerns the gene PPY and neoplasm.