Case 6 insulinoma consisted of oncocytic histological pattern with plump clear cells of less invasive tendency, which were linearly and patchy immunostained for CgA in 1% of tumor cell cytoplasm arranged parallel to the cell membrane, probably pushed by numerous mitochondria in the cytoplasm but diffusely stained for SPY (Figure 1D-F). The gene discussed is CGA; the disease is neoplasm.