One malignant PPoma, Case 1, from a multiple endocrine neoplasia-1 (MEN-1) family was solid pattern with moderately and granular staining for PP and moderately for CgA at 5% of tumor cell cytoplasm and diffuse strong staining for SPY (Table 2, Figure 3G-I). This evidence concerns the gene CGA and multiple endocrine neoplasia type 1.