The adjacent pancreas showed two types of islets, namely, normal islets and neoplastic islets, and the normal islet had the same size of cytoplasm of the other normal islets with the same dense CgA and SPY immunostaining, while the neoplastic islet had larger tumor cell cytoplasm with weaker and diffusely stained for CgA and SPY (Figure 2N and O). The gene discussed is CGA; the disease is neoplasm.