It is reported that miR‐377 targets E2F3 in malignant tumours.16 To further found the exact mechanisms why circPRMT5 can suppress function of miR‐377 to promote CRC development, we have been suggested that circPRMT5 may be responsible for promoting the expression levels of miR‐377 downstream targets E2F3 by acting as a miR‐377 sponge. Here, E2F3 is linked to colorectal carcinoma.