E2F3 serves as a potential transcriptional inducer of cell cycle progression, and its amplification was significantly associated with tumour progression.29, 30 Our study showed that the proliferation effect of circPRMT5 up‐regulation can be reduced by E2F3 inhibition, and the effect of miR‐377 inhibition can be suppressed by E2F3 inhibition. Here, E2F3 is linked to neoplasm.