MiR‐377 belongs to a large miRNA cluster whose expression is frequently silenced in human malignancies, such as neuroblastoma, ependymoma, gastro‐intestinal stromal tumours, osteosarcoma and prostate cancer.24, 25, 26, 27, 28 Further functional studies showed that miR‐377 inhibitor could functionally restore circPRMT5 silence‐suppressed CRC cells proliferation, and the oncogenic role of circPRMT5 in regulating cell cycle‐associated proteins CyclinD1 and CDK2 of CRC was partly dependent on the sponge activity of miR‐377. This evidence concerns the gene CDK2 and osteosarcoma.