RT‐PCR and Western bolt results showed that there was increase in CyclinD1 and CDK2 expression when the cells overexpressed circPRMT5 (Figure 3A,B), suggesting that cell cycle‐associated proteins CyclinD1 and CDK2 are involved in the oncogenic process of circPRMT5 in CRC. This evidence concerns the gene CCND1 and colorectal carcinoma.