Emerging evidence suggests that dysregulation of circRNAs plays a pivotal role in the development of malignancies.17, 18, 19, 20 Our results showed that up‐regulation circPRMT5 was a commonly oncogenic event in CRC, contributing to the cell proliferation by regulating cell cycle‐associated proteins cyclinD1 and CDK2. Here, CDK2 is linked to colorectal carcinoma.