Another study also showed that TIM‐3 facilitated osteosarcoma proliferation and metastasis through the NF‐κB pathway and EMT.40 Tan et al27 reported that TIM‐4 could drastically reduce E‐cadherin levels and promote the migration and invasion of colorectal cancer cells in vitro. The gene discussed is HAVCR2; the disease is osteosarcoma.