NPHS1 and diabetic kidney disease: Downregulation of nephrin is observed in experimental nephrotic models [28, 30–32] and in clinical cases of several types of glomerular disease such as minimal change disease [33], membranous nephropathy, membranoproliferative glomerulonephritis, IgA nephropathy, lupus nephritis [34], diabetic kidney disease [35, 36], and preeclampsia [37].