Furthermore, application of Vitamin D3 together with AIT significantly potentiates the beneficial in vivo tolerogenic responses in mouse models for allergic asthma, such as reduced airway hyperreactivity, airway eosinophilia, serum IgE, and Th2 cell responses, together with increased Treg cells and IL-10 in the lungs [107, 108]. This evidence concerns the gene IGHE and allergic asthma.