In NSCLC, Lu et al proposed that LINC00673 promotes TGF-β induced EMT by sponging miR-150-5p and thereby modulating ZEB1 expression indirectly.43 In addition, Roth et al have reported that LINC00673 negatively regulates p53 translation by directly interacting with its 3′UTR leading to senescence bypass.44LINC00673 can also regulate the expression of target genes epigenetically. This evidence concerns the gene TGFB1 and non-small cell lung carcinoma.