KLF4 and lung cancer: Notably, in lung cancer, LINC00673 represses HOXA5 expression through recruiting the epigenetic repressor EZH2 to its promoter region.47 Shi et al observed that LINC00673 epigenetically inhibited NCALD expression through direct binding to LSD1.42 In a similar way, in gastric cancer LINC00673 suppressed KLF4 expression by interacting with EZH2 and DNMT146 and direct binding to LSD1 and EZH2 repressed KLF2 and LATS2 expression.45