Our findings indicate that simultaneous suppression of miR-21 and upregulation of miR-7 exert synergistic anti-cancer effects on human GBM through inhibition of EGFR and p-AKT and activation of caspase- mediated pathways, lead to prolonged survival rate of mice bearing xenografts model of patient-derived GBM26. The gene discussed is EGFR; the disease is glioblastoma.