Since activation of VEGFR1 on leukocytes promotes leukocyte recruitment which contributes to leukocyte plugging41, sunitinib MP, which block both VEGFR2 and VEGFR1 and have a long duration of action, may be ideal for treatment of diabetic retinopathy in the absence of macular edema. The gene discussed is KDR; the disease is macular retinal edema.