In rho/VEGF mice with type 3 choroidal NV, photoreceptor cell death resulting in retinal atrophy is due to oxidative damage and while aflibercept does not increase photoreceptor death and loss of function, it does not significantly reduce photoreceptors death or maintain rhodopsin kinase, a critical component of the visual transduction cascade that is a marker for photoreceptor survival and function40. This evidence concerns the gene RHO and Retinal atrophy.