Interestingly, BRG1 negatively co-expressed genes were highly enriched in metabolic pathways, including vital hepatocyte functions, such as primary bile acid biosynthesis, drug metabolism, steroid hormone biosynthesis, etc. The result indicates that high BRG1 expression correlates with poorly differentiated status in human HCC (Fig. 2b). The gene discussed is SMARCA4; the disease is hepatocellular carcinoma.