One previous study reported that SULF2, a HS sulfatase, regulates Platelet Derived Growth Factor Receptor Alpha (PDGFRA) signaling and tumor growth in glioma19, whereas our recent findings indicate that Dermatan Sulfate Epimerase (DSE), a CS epimerase, is upregulated in glioma, and that it could regulate Erb-B2 Receptor Tyrosine Kinase 2 (ERBB2) signaling in cancer cells20. Here, SULF2 is linked to central nervous system cancer.