The NLRP3-AID spectrum includes three formerly distinct diseases: familial cold autoinflammatory syndrome (FCAS; MIM #120100), Muckle-Wells syndrome (MWS; MIM #191900), and Neonatal-onset multisystem inflammatory disease (NOMID) or chronic infantile neurologic cutaneous and articular (CINCA) syndrome (MIM #607115). The gene discussed is NLRP3; the disease is familial cold autoinflammatory syndrome.