Depending on their molecular mechanism, SAIDs can be separated into in-flammasomopathies or IL-1β-activation syndromes (FMF, NLRP3-AID, MKD, DIRA, DITRA), protein-folding disorders (TRAPS), NF-κB-activation disorders (Blau syndrome), interferonopathies (Aicardi-Goutières syndromes), and other cytokine-signalling disorders and complementopathies (i.e.: paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome) [21,35,36]. The gene discussed is NLRP3; the disease is TNF receptor 1-associated periodic fever syndrome.