With all three clinical cases, both 7G6 and E2814 robustly stained all the cognate pathological tau inclusions (Fig. 3 (E2814) and Additional file 1: Figure S5 (7G6)) including NFTs and neuropil threads in AD (Fig. 3 a-c) and NFTs as well as the TAs and CBs in PSP (Fig. 3 f-k). Here, MAPT is linked to Alzheimer disease.