In addition to AD fibrils, E2814 robustly decorated tau fibrils isolated from the frontal cortex of a frontotemporal dementia (FTLD-tau) patient with the MAPT missense mutation R406W (Additional file 1: Figure S8A), and another patient carrying the MAPT Δ280K deletion (Additional file 1: Figure S8B). Here, MAPT is linked to Alzheimer disease.