MAPT and supranuclear palsy, progressive, 1: The total score and domains of the PSPRS have been associated with PSP-related regional atrophy in the brainstem [18, 26, 49, 54] but not yet related to specific brainstem nuclei as the locus coeruleus [38] or in vivo tau pathology as measured via positron-emission tomography [19, 54].