MAPT and Alzheimer disease: The co-localization of p-tau and pCRMP2 has been reported in the brain tissue section of human AD, JNPL3 tau mouse, and 3xTg-AD rat models using a combination of AT8 and 3F4 (pCRMP2) [34], AT8 and pT509-CRMP2 or AT8 and pS522-pCRMP2 antibodies [35].We also observed co-localization of pCRMP2 and pS422 pTau in the CA1 field of Braak stage I specimen as determined by immunostaining of the adjacent sections of human brain tissue with 3F4 (pCRMP2) and PS422 (pTau, Fig. 1d).